ABSTRACT
Arboviruses cause public health problems in several countries, and records show that they can generate central and peripheral neurological complications with permanent sequelae. However, it is not certain which arbovirus is responsible for outbreaks of the Guillain-Barré Syndrome (GBS), especially in Brazil. Thus, the objective of this study is to verify if there is a coincidence between the GBS outbreak and the most common arboviruses in Northeastern Brazil, as well as their relationship. An ecological time series study was designed with the federative units of Northeastern Brazil, using hospitalizations for Guillain-Barré syndrome and notifications of arbovirus infections between 2014 and 2019 as a data source. Distribution incidence curves were constructed for the conditions studied, and generalized estimating equations (GEE) models were applied to estimate the relationship between arboviruses and Guillain-Barré. The results showed a similar distribution for the incidences of Chikungunya virus (z=7.82; p=0.001), Zika virus (z=3.69; p=0.03), and Guillain-Barré syndrome (z=2.98; p=0.05) from 2014 to 2019. The GEE model revealed that the distribution of Chikungunya incidence is associated with the distribution of GBS incidence in each year (x2Wald=3,969; p=0.046). This pattern was repeated in seven of the nine states, while the Zika virus had a significant relationship with GBS in only two states. The outbreak of GBS in Northeastern Brazil appears to be probabilistically related to outbreaks of the Chikungunya virus.
As arboviroses são problemas de saúde pública em vários países e há registros de que podem produzir complicações neurológicas centrais e periféricas com sequelas permanentes. Entretanto, não se sabe ao certo qual delas é realmente responsável pelos surtos da Síndrome de Guillain-Barré (SGB), principalmente no Brasil. Assim, o objetivo é verificar se há coincidência entre o surto de SGB e as arboviroses mais comuns no Nordeste do Brasil e suas relações. Foi desenhado um estudo ecológico de série temporal com as unidades federativas do Nordeste do Brasil, adotando como fonte de dados as internações Guillain-Barré e as notificações de infecções por arbovírus entre 2014 e 2019. Curvas de distribuição de incidência foram construídas para as condições estudadas, e foram aplicados modelos de equações generalizadas estimadas (GEE) para estimar a relação entre arbovírus e Guillain-Barré. Evidencia-se que há distribuição semelhante para as incidências do vírus Chikungunya (z=7,82; p=0,001), vírus Zika (z=3,69; p=0,03) e síndrome de Guillain-Barré (z=2,98; p=0,05) entre 2014 e 2019. O modelo GEE revelou que a distribuição da incidência de Chikungunya está associada à distribuição da incidência de SGB em cada ano (x2Wald=3,969; p=0,046). Esse padrão se repetiu em sete dos nove estados, enquanto o zika vírus teve uma relação significativa com o GBS em apenas dois estados. Conclui-se, então, que o surto de SGB no Nordeste do Brasil parece estar probabilisticamente relacionado aos surtos do vírus Chikungunya.
Los arbovirus causan problemas de salud pública en varios países y, según indican los reportes, pueden producir complicaciones neurológicas centrales y periféricas con secuelas permanentes. Sin embargo, no se sabe cuál de ellos es realmente el responsable de los brotes del síndrome de Guillain-Barré (SGB), especialmente en Brasil. Así, el objetivo de este estudio es verificar si existen coincidencias entre el brote del SGB y los arbovirus más comunes en el Noreste de Brasil y sus asociaciones. Se diseñó un estudio de series temporales ecológico en las unidades federativas del Noreste de Brasil, adoptando como fuente de datos las hospitalizaciones y las notificaciones de arbovirosis de Guillain-Barré entre 2014 y 2019. Se construyeron curvas de distribución de incidencia para las condiciones científicas, y se aplicó una ecuación estimada generalizada (GEE) para estimar la relación entre arbovirus y Guillain-Barré. Se encontró que existe una distribución similar en las incidencias de virus del chikunguña (z=7,82; p=0,001), virus del Zika (z=3,69; p=0,03) y síndrome de Guillain-Barré (z =2,98; p=0,05) entre 2014 y 2019. El modelo GEE reveló que la distribución de la incidencia de chikunguña está asociada con la distribución de la incidencia de SGB en cada año (x2Wald=3,969; p=0,046). Este patrón se repitió en siete de los nueve estados, mientras que el virus del Zika presentó una relación significativa con el SGB en solo dos estados. El brote del SGB en el Noreste de Brasil parece estar relacionado probabilísticamente con los brotes del virus del chikunguña.
ABSTRACT
Abstract Background Ischemic stroke and acute myocardial infarction (AMI) are cardiovascular diseases with high morbidity and mortality rates in Brazil and worldwide. Their outcomes are influenced by public policies aimed at mitigating risk factors and by investments in infrastructure of emergency support and quality of hospital care. Objective To analyze the trend in the proportion of in-hospital deaths from ischemic stroke and AMI in Brazil as a way of evaluating the effectiveness of urgency and emergency services. Methods Ecological time series study using data from the Hospital Information System. The outcome was the proportion of in-hospital deaths from ischemic stroke and AMI with stratification by sex and state. Prais-Winsten regression was used to analyze the trend between 1998-2018 with α≤0,05. Results The proportion of deaths from AMI and ischemic stroke declined in the time series (p<0.001), decreasing annually by 0.17% and 0.25%, respectively. In 20 years, it reduced 43.76% (ischemic stroke) and 32.39% (AMI) in both sexes. However, the decline was more evident in the South and Southeast regions. Conclusion The reduction in hospital deaths from AMI and ischemic stroke was heterogeneous among Brazilian regions, which may be related to inequality in emergency services and hospital support.
Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications , Labor, Obstetric , Pelvic Floor/injuries , Postpartum Period , COVID-19/epidemiologyABSTRACT
Introdução: Complicações diabéticas são condições preveníveis em sua maioria, sendo o pé diabético uma das mais comuns. O manejo adequado do pé diabético mitiga eventos incapacitantes e maiores gastos ao sistema de saúde. As intervenções efetivas na Atenção Primária à Saúde (APS) possibilitam prevenir as complicações diabéticas. Objetivo: Analisar a tendência das complicações do pé diabético e sua relação com a cobertura da APS nas capitais brasileiras, entre 2008 e 2018. Métodos: Estudo ecológico de séries temporais das incidências acumuladas de complicações do pé diabético nas 27 capitais utilizando dados do Sistema de Informação sobre Hipertensos e Diabéticos. As variáveis independentes foram ano, cobertura da APS e da Estratégia Saúde da Família. Empregou-se modelo de regressão de Prais-Winsten. Resultados: No Brasil, ocorreram 45.095 casos de complicações do pé diabético no período, com média de 0,57 casos/100.000 habitantes (p<0,001) estável em 14 capitais (p>0,05) e crescente em 13 capitais (p<0,05). Há associação entre elevação do nível de cobertura da APS e estabilidade na evolução das complicações diabéticas (p<0,05). Conclusões: Evidencia-se aumento da ocorrência das complicações do pé diabético, contudo, nas capitais com crescimento da cobertura da APS, houve controle da progressão.
Introduction: Diabetic complications are mostly preventable conditions, the diabetic foot being one of the most common. Proper management of the diabetic foot mitigates disabling events and higher costs to the health system. Effective interventions in Primary Health Care (PHC) make it possible to prevent diabetic complications. The care scenario for preventing diabetic complications is Primary Health Care (PHC). Objective: To analyze the temporal trend of diabetic foot complications and their relationship with PHC coverage in Brazilian capitals, between 2008 and 2018, and the relationship between them. Methods: An ecological time-series study of the cumulative incidences of diabetic foot complications in the 27 capitals using data from the Information System on Hypertensive and Diabetic Patients. The independent variables were year, PHC coverage and the family health strategy (ESF). A Prais-Winsten regression model was used. Results: In Brazil, there were 45,095 cases of diabetic foot complications in the period, with an average of 0.57 cases/100,000 inhabitants (p<0.001), being stable in 14 capitals (p>0.05) and 13 increasing capitals (p<0.05). There is an interaction between the increase in the level of PHC coverage and stability in the evolution of diabetic complications (p<0.05). Conclusions: Despite the increase in the occurrence of diabetic foot complications, however, in the capitals with growth in PHC coverage, there was control of the progression of diabetic foot complications.
Introducción: Las complicaciones diabéticas son en su mayoría condiciones prevenibles, siendo el pie diabético una de las más comunes. El manejo adecuado del pie diabético mitiga eventos incapacitantes y mayores costos al sistema de salud. Intervenciones efectivas en la Atención Primaria de Salud (APS) permiten prevenir las complicaciones diabéticas El escenario asistencial para la prevención de las complicaciones diabéticas es la Atención Primaria de Salud (APS). Objetivo: Analizar la tendencia temporal de las complicaciones del pie diabético y su relación con la cobertura de la APS en las capitales brasileñas, entre 2008 y 2018, y la relación entre ellas. Métodos: Estudio ecológico de serie temporal de las incidencias acumuladas de complicaciones del pie diabético en las 27 capitales utilizando datos del Sistema de Información de Pacientes Hipertensos y Diabéticos. Las variables independientes fueron el año, la cobertura de la APS y la estrategia de salud de la familia (ESF). Se utilizó un modelo de regresión de Prais-Winsten. Resultados: En Brasil, hubo 45.095 casos de complicaciones del pie diabético en el período, con una media de 0,57 casos/100.000 habitantes (p<0,001), manteniéndose estable en 14 capitales (p>0,05) y 13 capitales crecientes (p<0.05). Existe una interacción entre un aumento en el nivel de cobertura de la APS y la estabilidad en la evolución de las complicaciones diabéticas (p<0,05). Conclusiones: A pesar del aumento en la ocurrencia de complicaciones del pie diabético, sin embargo, en las capitales con crecimiento en la cobertura de la APS, hubo control de la progresión de las complicaciones del pie diabético.
Subject(s)
Time Series Studies , Diabetic Foot , Diabetes Complications , Primary Health Care , Ecological StudiesABSTRACT
Abstract Background: Atherosclerosis is a serious health problem, and several factors contribute to its occurrence. Longitudinal and qualified monitoring of primary health care (PHC) may contribute to the management of atherosclerosis and reduction of avoidable hospital admissions. Objectives: To estimate the trend in hospitalizations for atherosclerosis and the impact of PHC coverage on its evolution from 2008 to 2018 in Brazil. Methods: An ecological time series analytical study based on the outcomes of hospital admissions for atherosclerosis in Brazil. Time in years, PHC coverage, and Family Health Strategy (FHS) services were considered independent variables. A Prais-Winsten model was used to estimate the outcome trend, and α < 0.05 was adopted. Results: We observed a mean increase of 1.81 hospitalizations for atherosclerosis per 100 000 inhabitants annually (p = 0.002) in Brazil. This growth was evidenced in the Northeast (p < 0.001), Southeast (p = 0.003), and South (p < 0.001) regions, being stable in the North (p = 0.057) and Midwest (p = 0.62) regions. Men presented twice the growth in hospitalizations from the fifth decade of life on (p < 0.01). An inversely proportional relationship was observed for PHC coverage (B = -0.71; p < 0.001) and the proportion of FHS services (B = -0.59; p < 0.001) with the rate of admissions due to atherosclerosis in Brazil. Conclusions: Although hospitalizations for atherosclerotic complications are increasing in Brazil, they present regional and individual gender and age discrepancies, as well as a mitigating effect exerted by PHC coverage.
Subject(s)
Humans , Primary Health Care/methods , Atherosclerosis/complications , Atherosclerosis/prevention & control , Brazil/epidemiology , Time Series Studies , Environmental Health , Ecological Studies , Atherosclerosis/epidemiologyABSTRACT
A obesidade é um distúrbio metabólico crônico, multifatorial e complexo, no qual danos orgânicos podem ser evidenciáveis em curto ou longo prazo, destacando-se as afecções dermatológicas. Com o objetivo de verificar a associação entre o índice de massa corpórea e a presença de afecções dermatológicas em estudantes de uma escola pública do sertão Baiano. Tratou-se de um estudo transversal onde foram avaliados 169 escolares. O desfecho foram as afecções dermatológicas e as variáveis independentes o IMC, idade e sexo. Os dados foram analisados com qui-quadrado e α≤0,05. Cerca de 41 estudantes (24,3%) tinham baixo peso, 92 (54,4%) eutróficos e 36 (21,3%) obesos. Dentre as afecções dermatológicas, a estria se destacou com uma prevalência de 58%, seguida da celulite 26% e acne 24,3%. A faixa etária (14-20 anos) esteve significativamente associada com os valores do IMC (p=0,05). Do mesmo modo que a acantose (p=0,05), estrias, hidradenite e celulite também apresentaram relação significativa com o IMC (p=0,01). Houve significância estatística (p=0,01) quando comparada a presença de até seis dermatoses com os grupos baixo peso, eutrófico e obeso. Determinadas afecções dermatológicas estiveram significativamente associadas ao IMC. É necessário que sejam realizadas ações educacionais de conscientização e prevenção direcionadas para estes jovens que levem a uma redução dos casos de obesidade, tendo em vista que neste grupo as alterações dermatológicas foram mais evidentes.
Obesity is a chronic, multifactorial and complex metabolic disorder, in which organic damage can be evident in the short or long term, especially dermatological disorders. With the objective of verifying the association between the body mass index and the presence of dermatological conditions, students at a public school in the backcountry of Bahia were studied. This was a cross-sectional study in which 169 schoolchildren were evaluated. The outcome was skin conditions, and the independent variables were BMI, age, and sex. Data were analyzed with the chi-squared test and an α≤0.05. About 41 students (24.3%) were underweight, 92 (54.4%) were eutrophic, and 36 (21.3%) were obese. Among the dermatological conditions, stretch marks stood out with a prevalence of 58%, followed by cellulite with 26%, and acne with 24.3%. The age group (14-20 years) was significantly associated with BMI values (p=0.05). Similarly, acanthosis (p=0.05), striae, hidradenitis, and cellulite also showed a significant relationship with BMI (p=0.01). There was statistical significance (p=0.01) when the presence of up to six dermatoses was compared with the low weight, eutrophic, and obese groups. Certain skin conditions were significantly associated with BMI. It is necessary to carry out educational awareness and prevention actions aimed at these young people that lead to a reduction in obesity cases, considering that in this group the dermatological changes were more evident.
ABSTRACT
A dor neuropática é causada por uma lesão ou doença do sistema nervoso somatossensitivo. Trata-se de uma manifestação sindrômica que envolve mecanismos inflamatórios e imunes com fisiopatologia ainda pouco esclarecida. O espectro de apresentação da dor neuropática é amplo e, assim, constitui um desafio na prática clínica. Este problema de saúde pública necessita de ampla capacidade técnica dos clínicos generalistas. Torna-se relevante identificar o potencial de cronificação do sintoma e adotar abordagens mitigantes do processo lesivo, estrutural e emocional. Nesse sentido, o diagnóstico adequado da dor neuropática é o primeiro passo na abordagem ao paciente. Diante disso, essa revisão objetiva facilitar a melhor escolha dos métodos diagnósticos no manejo clínico do paciente. Dentre estes, é possível citar a imagem por ressonância magnética funcional, eletroneuromiografia, tomografia por emissão de pósitrons, microneurografia, teste quantitativo sensorial, biópsias de pele, estudos de condução nervosa e de potencial somatossensorial evocado. A dor, por ser um processo sensorial subjetivo, apresenta amplo espectro de manifestações clínicas. Por essa razão, é possível fazer uso de técnicas como métodos de triagem e exames complementares para um diagnóstico mais específico.
Neuropathic pain is caused by an injury or illness of the somatosensory nervous system. It is a syndromic manifestation that involves inflammatory and immune mechanisms, whose pathophysiology is still poorly understood. The spectrum of presentation of neuropathic pain is wide and, therefore, it is a challenge in clinical practice. This public health problem requires the broad technical capacity of general practitioners. It is relevant to identify the potential for chronicity of the symptom and adopt mitigating approaches to the harmful, structural, and emotional process. In this sense, the proper diagnosis of neuropathic pain is the first step in approaching the patient. Therefore, this review aims to facilitate the best choice of diagnostic methods in the clinical management of the patient. Among these, functional magnetic resonance imaging, electroneuromyography, positron emission tomography, microneurography, quantitative sensory testing, skin biopsies, nerve conduction and evoked somatosensory potential studies are possible. Pain, being a subjective sensory process, has a wide spectrum of clinical manifestations. For this reason, it is possible to make use of techniques such as screening methods and complementary exams for a more specific diagnosis.
Subject(s)
Humans , Somatosensory Cortex , Central Nervous System Diseases/diagnostic imaging , Chronic Pain/diagnosis , Nervous System/physiopathology , Parasympathetic Nervous System , Central Nervous System , Triage , Neuroimaging/methods , Nerve Conduction StudiesABSTRACT
Abstract Background Stroke and acute myocardial infarction (AMI) are cardiovascular diseases commonly characterized by the development of atheromatous plaques associated with major complications and high mortality rates. Objective To identify an epidemiological trend in hospitalizations due to stroke and AMI and to analyze the relationship between health programs applied in Primary Health Care, gender and the Federative Unit. Methods Ecological study with a time series design between 1998 and 2018, collecting data from all federal units in Brazil stratified by, gender and place of residence. There were analyzed Hospitalization Authorizations (AIH) for stroke and MI, consulting the Hospital Admissions System (SIH) of the Informatics Department of the National Health Service with p <0.05. Results From 1998 to 2018, the rate of hospitalization for AMI increased in Brazil approximately 42.58 events per 100 thousand inhabitants annually (p<0.001), while hospitalizations for stroke declined 32.17 cases (p=0.03). This pattern was observed in both sexes in AMI and stroke. There is also evidence of the effect of the Hiperdia (p<0.001) and Mais Médicos (p=0.001) program in reducing stroke and Hiperdia cases in mitigating the evolution of AMI cases (p = 0.0001). Conclusion Although these diseases remain as an important cause of death, stroke hospitalization has reduced significantly in the period evaluated. National programs as the Hiperdia and Mais Médicos showed an impact in the acute cases of strokes and AMI.